A Flagship Pioneering Company
Generating tomorrow’s medicines today
We work at the frontier of programmable medicines. We power our bioplatform and product candidates by harnessing evolution and AI. We operate with purpose and urgency on behalf of people everywhere. We aim to generate life-changing impact for the world.
Our scientists created a platform to unlock the therapeutic power of eRNA & TNPs
Sail has built the most complete toolkit in the industry to comprehensively program RNA medicines. The Sail platform enables both programmable pharmacology with translatable circular RNA technology (Endless RNA™ or eRNA™), and programmable deployment via targeted nanoparticles (TNPs) equipped with disease-specific targeting ligands. By leveraging our rapid prototyping and testing bioplatform, Sail is building a wealth of data, enabling unparalleled use of proprietary AI algorithms for the integrative design of RNA medicines.
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endless rna
Programmable pharmacology with eRNA – a new class of medicine
Sail is pioneering eRNA – a new class of translatable and stable RNA that can be programmed to express diverse proteins inside the body with prolonged expression. Due to its circular structure, eRNA is protected from exonuclease degradation, leading to durable expression, and thereby expanding the programmability and therapeutic potential of RNA.
02 nanoparticles
Enhanced deployment with programmable nanoparticles
Sail’s targeted nanoparticles (TNPs) are built on a modular nanoparticle core and programmed with targeting ligands that recognize cell-specific surface markers. The TNPs circulate systemically, internalize in the targeted cells, and release their eRNA payload efficiently through endosomal escape. The same nanoparticle core has been validated with dozens of targeting ligands, creating a modular toolkit for precise, repeatable deployment across diseases.
03 artificial intelligence
Integrative generation of fully programmable RNA medicines, powered by AI
Sail is using building and deploying proprietary generative AI technologies technology and coupled with rapid prototyping abilities iterative learning to achieve breakthroughs currently beyond the grasp of the human mind. With our unique combination of cutting- edge technologies and data generation capabilities, Sail is advancing integratively designed RNA medicines for the potential treatment of autoimmune, metabolic, infections and rare diseases, aiming at unlocking unprecedented performance.