A Flagship Pioneering Company

Generating tomorrow’s medicines today through the language of life

We work at the frontier of programmable medicines. We power our bioplatform and product candidates by harnessing evolution and AI. We operate with purpose and urgency on behalf of people everywhere. We aim to generate life-changing impact for the world.

Our Science

We will unlock fully programmable medicines with unprecedented performance

Sail has built the most complete toolkit in the industry to comprehensively program RNA medicines. The Sail platform enables both programmable pharmacology with first-in-category translatable circular RNA technology (Endless RNA™ or eRNA™), and programmable deployment with broadly expanded natural chemistries for nanoparticle design. By leveraging our rapid prototyping and testing bioplatform, Sail is building a wealth of data, enabling unparalleled use of proprietary AI algorithms for the integrative design of RNA medicines.

Programmable pharmacology with first-in-category Endless RNA

The Sail platform is pioneering Endless RNA – a new class of translatable and stable RNA that can be programmed to express diverse proteins inside the body with prolonged expression. Due to its circular structure, eRNA is protected from exonuclease degradation, leading to durable expression, and thereby expanding the programmability and therapeutic potential of RNA.

Enhanced deployment  with first-in-category programmable nanoparticles

By leveraging the vast molecular diversity that comes from nature, Sail is creating a fundamentally new approach to nanoparticle programming, utilizing a much broader set of chemistries than ever before. Sail’s proprietary nanoparticles demonstrate the potential to enable unique tropism, a wide range of routes of administration, and frequent re-dosing of RNA with sustained expression.

Integrative generation of fully programmable RNA medicines, powered by AI

Sail is using building and deploying proprietary generative AI technologies technology and coupled with rapid prototyping abilities iterative learning to achieve breakthroughs currently beyond the grasp of the human mind. With our unique combination of cutting- edge technologies and data generation capabilities, Sail is advancing integratively designed RNA medicines for the potential treatment of autoimmune, metabolic, infections and rare diseases, aiming at unlocking unprecedented performance.